Eddie Howe will be without Harvey Barnes, Joe Willock and Sven Botman for their clash with PSG.
Callum Wilson has missed the last two matches due to a minor hamstring issue but could feature in the glamour tie with the French giants.
Joelinton made his return from injury on Saturday against Burnley but the Brazilian only lasted four minutes before being withdrawn.
Anthony Gordon is available for Wednesday night but will be suspended for Newcastle’s next Premier League game against West Ham.
Kylian Mbappe played 90 minutes against Clermont after shaking off an ankle issue and is likely to start at St James’ Park.
Luis Enrique will be without Nuno Mendes, Marco Asensio, Presnel Kimpembe and Sergio Rico for their trip to Tyneside.
Hello and welcome to SunSport’s live blog of Newcastle vs PSG!
The Magpies are gearing up for their first Champions League match on Tyneside for over 20 years.
Tonight’s opposition doesn’t get much more difficult as Eddie Howe’s side welcome French champions PSG to St James’ Park.
Newcastle returned to Europe’s elite competition with a 0-0 draw away at AC Milan to claim their first point in Group F.
Since then, the Toon have been in fantastic form, winning their last three in all competitions.
PSG sit at the top of Group F ahead of tonight’s games after beating Borussia Dortmund 2-0- in their Champions League opener.